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Avandia Linked to Bone Fracture and Osteoporosis Risk

Millions of Americans suffer from a form of diabetes, and with increasing waistlines comes an increase of type 2 diabetes especially. However, there are many type 2 diabetes drugs available on the market including Avandia. However, Avandia has been linked to everything from heart disease to bone fractures. And, the bone fractures as well as early onset osteoporosis was recently associated with conclusive evidence from a Swiss research study.

In 1999, Avandia became available from manufacturers GlaxoSmithKline and was given to nearly 3.5 million Americans suffer from the condition. Avandia was once considered one of the most popular treatments until results of several clinical trials reported in the news in 2007 determined a strong connection of the drug to cardiomyopathy and cardiovascular disease. One study, published by the Cleveland Clinic, found a 43 percent increase for patients developing these various heart diseases. Dr. Of the thousands of myocardial infacractions that have occurred over the last few years, nearly 83,000 may have been preventable, according to John Buse, a diabetes expert.

It wasn't until the Swiss research that conclusive evidence was reported on the serious risk of osteoporosis link. The Swiss study determined patients on Avandia and Actos, which is also part of the Avandia class of drugs known as thiazolidinediones, doubled and, in some cases, tripled the “odds of non-spine fractures” among patients, according to news reports. For patients who took the drug for 12 to 18 months, this risk increased, and for those on the drug longer than two years were found to be at the highest risk of bone fracture and osteoporosis.

Osteoporosis is a disease characterized by loss of bone density and leads to abnormally porous bones, thus increasing the fragility of bones and an increase of fractures and breaks. A bone diseased with osteoporosis will have a density similar to that of a sponge, whereas healthy bones have a brick-consistent density level. Bones are made up of collagen, calcium and protein to ensure strength. Avandia was found to inhibit the development of osteoclasts and osteoblasts, which are cells that induce the redevelopment of healthy bone over time. Nearly 18 million U.S. citizens are at risk for osteoporosis. While taking Avandia, that risk has been suggested to only increase.

The Swiss researchers used medical records of over 1,000 diabetic patients who were diagnosed with bone fractures between the years of 1994 and 2005. The medical records included diagnosis of fractures for these patients from British physicians, and the research was compared to a control group of diabetics that did were not diagnosed with bone fractures during that time. Avandia, once an extremely popular form of type 2 diabetes treatment, now is rapidly declining in popularity and in sales because of surfacing side effects. Most recently, the U.S. Food and Drug Administration (FDA) conducted a routine inspection that brought about information of results being withheld on the drug, thus the FDA issued manufacturers GlaxoSmithKline a warning letter.

However, the risk of osteoporosis and Avandia consumption has not be recognized by the FDA. In fact, the FDA has only responded to the controversial heart disease link by placing a black box warning on Avandia prescriptions, which some health experts consider to be a mild slap on the wrist considering the severe safety issues associated with the drug and many of these individuals are advocating removal of the drug from the market. The black box warning is the strongest label given by the FDA and warns of significant risk and the potential for life-threatening risks associated with taking a drug.

Individuals who have taken Avandia and who were adversely affected by the side effects of osteoporosis and bone fracture should speak with a pharmaceutical attorney about developing Avandia litigation to potentially receive monetary compensation for the medical bills incurred at the cost of the Avandia side effects.

Article Source: http://www.newagelivingarticles.com

To learn more about Avandia and the link to osteoporosis, visit avandia.legalview.com/. Also peruse LegalView's additional legal issues ranging from news updates on the Baxter Heparin contamination to mesothelioma cancer, which affects thousands of Americans between the average ages of 50 and 70 years old each year. Use mesothelioma.legalview.com for more information.

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